Description

Johns Hopkins Drug Discovery is seeking a postdoctoral fellow to join a fun and highly collaborative team developing new therapeutics for neurodegeneration, particularly Alzheimer’s disease.

Johns Hopkins Drug Discovery operates like a startup biopharma company within Johns Hopkins University. Our team includes medicinal chemists, biologists, pharmacologists, DMPK scientists, and in vivo pharmacologists working together to move early therapeutic ideas toward clinical development. The group has advanced multiple drug discovery programs, moved drugs into clinical trials, and helped launch several biotechnology companies.

This position is ideal for a broadly trained experimental biochemist or cell biologist with an interest in translational science and drug discovery. The fellow will contribute to projects focused on Alzheimer’s disease, lipid dysregulation in the brain, and APOE4. This role is perfect for someone seeking a career in the biopharma industry or in academic drug discovery.

Requirements

• Lead therapeutic discovery projects for Alzheimer’s and rare neurodegenerative diseases.
• Develop, optimize, and troubleshoot molecular, biochemical, cell-based, and tissue-based drug screening assays.
• Test candidate therapeutics in models relevant to Alzheimer’s disease, neurodegeneration, and radiation-induced brain injury.
• Perform molecular biology and biochemistry techniques such as enzymatic assays, Western blotting, immunofluorescence and immunohistochemistry.
• Use microscopy and image analysis to quantify disease-relevant phenotypes.
• Conduct cell-based experiments to assess functional activity of drug candidates.
• Support mouse studies, including colony management, breeding, genotyping, dosing, behavioral studies, tissue collection, and tissue processing as needed.
• Analyze drug effects on neurodegeneration, inflammation, lipid accumulation, tau pathology, tissue injury, and repair.
  Work with collaborators and external partners on studies involving mouse models, organoids, stem cell models, and other disease-relevant systems.